What Are Nootropics?

Nootropics are substances that improve some aspect of cognitive performance. Memory, learning, focus and perception are just some of the areas these supplements can enhance. Different types of nootropics can work on different neurotransmitters and parts of the brain. For this reason, they are often combined to create a synergistic “stack”. You can buy nootropics here

Nootropics are not to be confused with stimulants as they generally have little effect on the central nervous system. This is a main distinction between nootropics and other substances as they are considered to much safer and lower in toxicity than other brain enhancing supplements. Visit our blog to learn more about our products and their exact modes of action.

 

How Do Nootropics Work?

There are many types of nootropics with different mechanisms of action. This is because there are different neurotransmitters and systems involved in cognitive performance. Changing the level of certain neurotransmitters and how they interact with receptors can influence how our brain functions.

Acetylcholine is an important neurotransmitter in the brain. It plays a large role in cognitive functioning such as, learning and memory. Aside from this, acetylcholine is extremely important in muscle coordination and movement. Acetylcholine binds to two receptor sites known as the nicotinic and muscarinic receptors. Certain nootropics like the racetam group bind to these receptors and increase the signal output of acetylcholine. These types of brain enhancers are known as positive allosteric modulators of the acetylcholine receptors.

 

Safety & Side Effects

In general, nootropics are considered very safe. They are not stimulants or psychoactive compounds as these types of substances do not follow the same guidelines of safety. A stimulant like Adderall for instance, cannot be considered a nootropic even though it can help with performance and productivity. Below is a list of the most common side effects, which usually manifest in larger dosages.

  • Headache
  • Nausea
  • Gastrointestinal Problems
  • Depression
  • Irritability

 

 

 

 

All things need to be looked at when evaluating a nootropics’ safety profile. They are non-psychotropic and therefore have very little negative interactions with the central nervous system. Cases of addiction, tolerance and withdrawal symptoms are also extremely rare with nootropics. With this said, side effects may still occur and it is always best to follow best practices when using these. supplements.

 

Racetam Nootropics

The most common and well known group of nootropics that binds to acetylcholine receptors are known as the racetams. Racetams boost cognition by primarily binding to the two types of ACh receptors. In the group of racetams there are several that have been around for a long time such as piracetam. Since the creation of piracetam, many other more advanced racetams have been created. Below is a list of the most popular racetam nootropics.

  • Piracetam
  • Aniracetam
  • Oxiracetam
  • Pramiracetam
  • Phenylpiracetam

 

 

 

 

Acetylcholine Nootropics

Acetylcholine is synthesized in the body from the natural compound, choline which can be obtained through a healthy diet. It is possible that may people lack the proper diet to produce enough choline and this may result in cognitive issues. There are certain supplements that influence the amount of acetylcholine either through boosting natural choline levels, or by working on the synthesis of acetylcholine through other intermediate factors

Generally, the best method to increase acetylcholine is to use an advanced acetylcholine boosting compound as opposed to taking choline alone. Choline and related phospholipids are generally not considered nootropic unless it is deficient in the body. Also, consuming more choline will not necessarily relate to higher acetylcholine levels.

Several acetylcholine boosters like alpha GPC and citicoline and considered nootropics when taken alone and these compounds will offer even better nootropic benefits when combined with an effective ACh binder like the racetams

By far the best result would be to make an acetylcholine-racetam nootopic stack. This stack involves combining an acetylcholine receptor binder with and acetylcholine boosting supplement. This allows for a higher amount of acetylcholine to bind to the receptors. While there is no direct scientific evidence, some state that combining these two in a stack can reduce common side effects like headache often attributed to low amounts of acetylcholine in the brain.

Glutamate is another important cognitive neurotransmitter. It is much more abundant than acetylcholine and unlike acetylcholine boosting supplements boosting glutamate levels in the brain will not necessarily produce nootropic effects. It is the binding to glutamate receptors that is theorized to create nootropic advancement.

Some nootropics target the AMPA and NDMA glutamate receptors. These types of nootropics are known as the ampakines and there development is of much interest to the medical community as of late.

 

Ampakine Nootropics

Glutamate is another important cognitive neurotransmitter. It is much more abundant than acetylcholine and unlike acetylcholine boosting supplements boosting glutamate levels in the brain will not necessarily produce nootropic effects. It is the binding to glutamate receptors that is theorized to create nootropic advancement.

Some nootropics target the AMPA and NDMA glutamate receptors. These types of nootropics are known as the ampakines and there development is of much interest to the medical community as of late.

Ampakines act as positive allosteric modulators at the AMPA and NDMA receptor sites. There has been a lot of debate recently as to how these functions apply to cognition and memory. It is believed that ampakines may influence LTP (long term potentiation) by indirectly influencing cAMP levels. If this is true, ampakines may greatly influence cognitive performance. Human studies on certain ampakine nootropics have shown positive improvements in cognitive function after treatment.

Ampakines are currently under intense research and safety must be evaluated before people should even consider using them. Many feel glutamate excitotoxicity may be an issue however some of the never compounds have shown to have very little if any in certain studies.