Many nootropic users will build a stack to increase the overall effectiveness of each supplement. The end goal of a stack is to produce the best effects at the cheapest costs. There are some supplements that go good together and some that do not. Synergy is the key and this article will outline some of the best stacks to potentiate each other.
Piracetam is a great nootropic to stack because it is cheap and widely available. It also goes well with a lot of other supplements. Aniracetam compliments piracetam quite well and the two are commonly stacked. Oxiracetam and aniracetam may also be stacked together with piracetam as this creates a very powerful stack with unique properties of each racetam.
Choline goes well in a piracetam stack. Alpha gpc, citicoline, choline bitartrate, ALCAR and centrophenoxine will all compliment piracetam well. Acetylcholinesterase inhibitors may also go well with piracetam.
Piracetam may also be stacked with other non-cholinergic nootropics. Ampakines like sunifiram can be stacked with piracetam however, neither potentiate each other. Other stimulant nootropics like sulbutimaine and caffeine may also add some “kick” to a piracetam stack.
Noopept is a pretty powerful cholinergic nootropic that works well on its own. Some of the weaker cholinergic compounds like piracetam do not go well with noopept. Aniracetam and noopept may be stacked together as they may produce synergy as an anxiolytic due to their effects on 5HT (serotonin) receptors.
Otherwise, noopept in generally stacked with acetylcholine and choline boosting compounds. Noopept like other cholinergics, creates an increased demand on the cholinergic system. This demand is thought to be a caused of headaches. The best choline compounds to stack with noopept are alpha GPC and citicoline.
Pramiracetam is one of the strongest racetams. Stacking pramiracetam with piracetam, aniracetam or oxiracetam is generally considered a waste. This is due to the fact that pramiracetam is already very strong and using other racetams will cause an overlap in effects.
Stacking pramiracetam with other types of nootropics like ampakines and dopaminergics will offer a better change of increased cognitive effects. It may be stacked with sunifiram and sulbutiamine to increase the scope of the stacks effectiveness.
Choline compounds can also be stacked for increased effectiveness. Citicoline and alpha GPC are usually not used together in a choline stack. Both of these choline compounds are very effective at converting into acetylcholine and they are also very costly.
Some people will stack weaker choline compounds like choline bitartrate with ALCAR (acetyl l-carnitine) together. Choline and ALCAR go well together because ALCAR may help with the conversion of choline into acetylcholine. This combination is said to be very effective.
Racetams work as some of the best nootropics to stack. Like mentioned above, some will work to potentiate the others and some will just work against each other. Not every person will find the same results with a racetam stack. The best option is to try each racetam and build a stack around the one that offer the best effects.
Generally, all racetams will stack well with choline compounds. Some may find that choline may stack well with their racetam stacks. It is thought that an overload of acetylcholine can influence mood and therefore this stack may depend largely on the individual.
One may also choose to stack racetams with acetylcholinesterase inhibitors like huperzine A. Stacking racetams with acetylcholinesterase and choline compounds may increase the chance of side effects so this stack must be handled with care.
If your desire is to create or add some anxiolytic functions into your stack there may be some great options. The effectiveness of the anxiolytic stack will depend largely on the method and orgin of the anxiety. Some anxiety may stem from chemical imbalances and increasing the activity of certain neurotransmitters (serotonin, GABA) may reduce the activity of this anxiety.
One great product for anxiety is phenibut. Phenibut is commonly sold beside piracetam however it is not considered to be a nootropic contrary to popular belief. Regardless, it is often used in conjunction or added to a nootorpic stack for its sedativie properties.
Aniracetam and noopept may have some function on selective serotonin receptors. Studies have shown some anxiolytic properties in animals.
L-theanine is another great nootropic with anxioytic functions. It is isolated from tea leaves and thought to be the main culprit behind teas subtle calming abilities. L-theanine actually acts as a nootropic and calming agent without causing excessive sedation. It is considered to be one of the best anxiolytic nootropic supplements.