You may be deciding between piracetam and aniracetam. Perhaps you cannot afford to buy both or are simply just looking for a general comparison between the two supplements. Both piracetam and aniracetam have a lot of similarities and differences to evaluate.
In terms of popularity, piracetam is much more popular than aniracetam as a nootropic. This does not mean that piracetam is better than aniracetam but simply means that piracetam gets more publicity and widespread use. Aniracetam is the next most popular racetam next to piracetam. Regardless of this, piracetam is still over three times as popular as piracetam.
Piracetam also has a big advantage over aniracetam in the popularity department. It has been around longer and has many more studies than aniracetam. Since it was the first racetam developed it is often mentioned in a lot more in literature. Also, piracetam has been approved for a lot more medical uses in countries that have registered it as a drug which gives it even further publicity
Aniracetam is stronger in potency than piracetam. The average dosage is slightly smaller than with piracetam. Most people will dose 750-1500mg in comparison to 800-3000mg with piracetam. Piracetam is water soluble which means it is best taken on an empty stomach whereas aniracetam is fat soluble and best taken with food.
The bioavailability and half-lives of both substances are very different. Piracetam has a very good oral bioavailability of near 100% whereas aniracetam only has an oral bioavailability of 8.5%-11.5%. This is due to the fact that aniracetam is subject to a first pass metabolism in the liver. Piracetam has a half-life of 4-5 hours in comparison to aniracetam which has a short half-life of 1.5-2.5 hours.
Aniracetam is stronger than piracetam regardless of the much lower bioavailability and half-life. Both of these nootropic racetams act similarly on cholinergic pathways by acting as positive allostertic modulators of the acetylcholine receptors. The cholinergic effects may seem quite similar with possible increases in learning, memory and sensory perception. Piracetam is slightly stronger than aniracetam as a cholinergic nootropic.
Piracetam has little if any effects on glutamatergic systems. Aniracetam on the other hand acts as a modulator of the AMPA glutamate receptor. The ampakine-like activity of aniracetam may explain its slightly stronger benefits despite its lower half life and bioavailability.
Aniracetam may also affect certain serotonin receptors in conjunction with acetylcholine and glutamate receptors. This might explain possible anxiolytic (anxiety reducing) effects observed in animal models. This may be an added benefit of aniracetam that some people may experience. The benefit of this is that aniracetam may promote these effects without any sedation or inhibition of the mind.
Both piracetam and aniracetam are very safe supplements. They are some of the oldest racetams with several decades of published use. Neither have very high potential of overdose or addiction. One must still be careful when using these two as both can produce side effects especially evident in higher dosages.
The side effects of piracetam and aniracetam are likely to be similar. Headaches, nausea, depression and irritability may all be common. Both may also stimulate brain fog possibly due to the cholinergic hyperactivity caused by an off balance in catecholamine homeostasis. This might be able to be solved with certain tweaking and neurotransmitter support in sensitive individuals.
Both aniracetam and piracetam are different. When comparing which is a better nootropic, aniracetam will likely win due to its wider scope of benefits. Aniracetam is becoming increasingly more popular however it is likely to remain less popular than piracetam in the future.
Aniracetam and piracetam are great racetams to stack together. Both of these nootropics are very affordable and are well tolerated in most users. Stacking them together will allow for a wider range of effects overlapping into the cholinergic, glutamatergic and serotonergic systems. Adding in a choline stack with these two racetams may help to potentiate the effects even further.