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Sulbutiamine is created by synthetically combining two modified vitamin B1 molecules. Vitamin B1, also known as thiamine is an essential vitamin in the B class. Thiamine is very important within the body and helps in the creation of acetylcholine in the brain.

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While created from thiamine, sulbutiamine does not have the exact same effects due to its unique chemical properties. It has a higher bioavailability when compared to thiamine and crosses the blood brain barrier more easily due to its structure. The effects of the sulbutiamine are also thought to be greatly enhanced and unique in comparison to thiamine.

How it Works

It is thought that sulbutiamine affects cholinergic and glutamatergic signaling. Studies in rats have shown it to positively increase glutamate neurotransmission in corticol regions of the brain. These regions are important and prominent in decision making and other areas of cognitive functioning. Another study showed that rats injected with sulbutiamine had a slight increase in cholinergic uptake in the hippocampus.

Sulbutimaine is unique to other nootropics because it seems to also affect dopaminergic neurotransmission. Studies have shown rats treated with the nootropic had a decrease in brain levels of dopamine. Strangely, no changes were observed in the dopamine receptors. This is an area that needs more study to fully understand the inner-workings of the supplement


Sulbutiamine can be seen to have many benefits consistent with the other racetams. Memory and learning may be improved. Focus, attention and decision-making may also be affected. It is considered to be a great supplement for motivation because it is regarded to affect energy levels.

There are some differences in the benefits of sulbutiamine not seen with other nootropics. It is seen to have some energy enhancing effects. This is likely to be caused by the dopaminergic signalling. Unfortunately, these effects also lend the supplement to have more side effects than other nootropic supplements.

Side Effects

Sulbutiamine is a nootropic and therefore it is generally considered to be very safe. Although this is true, it is considered to have more side effects than racetams and ampakines. Some of the side effects of sulbutiamine are likely to appear in higher dosages or when the supplement is used continuously without cycling.

Sulbutiamine is said to have mood enhancing effects but in others, it may work in an opposite manner. Anxiety may be provoked due to the slight stimulating effects however this is more likely to occur in very sensitive individuals. Irritability is also commonly reported possibly due to cholinergic overstimulation.


Subutimaine is a safe supplement when used at the recommended dosages however problems can still occur. There is at least one documented case of addiction however this evidence may not be unreliable. The supplement is thought to cause a tolerance build-up overtime however becoming addicted to it is a very rare problem. Cycling this supplement is the best way to use it as it may help to reduce tolerance and associated problems.

Overdosing on sulbutiamine may cause some uncomfortable side effects. Subutiamine overdose may happen at 1.5 – 2 times the recommended dosage. Usual overdose effects may include: anxiety, insomnia, irritability and nausea. There are no known reports of sulbutiamine fatality from overdose or drug interactions.


Sulbutiamine stacks very well with a large range of nootropics. Its effects may compliment any nootropic stack quite nicely. Many people may add it to their regimens and cycle it during times of need. It may work well in a nootropic stack by adding in some energetic effects while also enhancing focus and decision-making skills.

Many people may choose to stack sulbutiamine with cholinergics. The substance works to slightly improve cholinergic uptake and therefore its combination with other racetams may be slightly synergistic. There is no limit to which type of nootropic people may stack it with. Sulbutiamine is commonly stacked with: piracetam, aniracetam, oxiracetam, pramiracetam and noopept.

Sulbutiamine and its cousin, pyritinol are said to have synergetic effects. This information may not be entirely true. Both supplements are somehow related to the structure of B vitamins however both have different modes of action. Regardless of this, these two are also commonly stacked together.

Legal Status

In most countries sulbutiamine can be obtained over the counter as a supplement. It is legal to obtain as a supplement within the United States and it is considered a supplement under American law. In Canada the supplement has no registration with Health Canada however it can be imported legally into the country for personal use. The substance is not listed or scheduled within Australia or the UK and may be imported legally into both countries.

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