A review of Pemoline: effects, side effects, dosage and results
Pemoline is a nootropic substance with a tradition of about a hundred years. It was first synthesized in 1913 and used as a prescription medicine under numerous market names. Its use was focused on the treatment of children with ADHD and its mechanism aimed towards the stimulation of the central nervous system and increasing attention in combination with a decrease in restlessness. Even though it has been discovered a hundred years ago, its past usage was not based on the definite mechanism of action (which was still unknown and unexplained), a couple of decades after its discovery.
Nowadays, experts believe that Pemoline is not safe for children, so it was abandoned as treatment for ADHD as well as narcolepsy. Current classification puts this substance in the psychotropic group and is administered intravenously in the U.S.A.
The effects of Pemoline
Pemoline’s mechanism of action is still not fully explained, even though it has been used for a hundred years already in medicine. But, the effects of Pemoline are certain. It works as a powerful brain stimulant. When compared to other nervous stimulants, Pemoline has a different pharmacological activity, which vastly differs from other compounds. Having small molecules enables Pemoline to easily cross the blood brain barrier and act inside the central nervous system quickly and efficiently. It also acts as a surrogate for the neurotransmitter dopamine, without affecting the intracellular concentrations of dopamine at all. This also explains the reason why it has minimal effects on significant dopamine stimulation. Therefore, it doesn’t bear typical side effects such as loss of appetite, hypertension, dry mouth, cardiac stress, dilated pupils, and smooth muscle constriction.
An important effect of Pemoline, which a vast majority of scientists support, is its nootropic effect. Scientists believe that Pemoline works as a nootropic agent or as a supplement, acting as a catalyst conductor of brain synapses placed in the memory section. This way, Pemoline affects the production and formation of RNA, which raises memory efficiency needed for positive cognitive function.
The previous benefits of this substance could be found in the treatment of ADHD/ADD in children, but it is now considered unsafe for the youngest group of our population. The effect which stood behind this treatment was the expanded attention span of children when they were using their substance. This improved the cognitive function of children and helped them to stay focused, overcoming the negative sides of the syndrome. Their overall emotional stability was also positively affected, as well as their calmness and stressfulness. From time to time, Pemoline was also used in the treatment of narcolepsy, with the same benefits present with the children who suffer from ADHD/ADD.
One of the most significant benefits of this substance is its nootropic activity, which is increasingly popularizing this chemical substance nowadays. The proposed mechanism which classifies this substance as a nootropic substance is its effect on the development of the synapses in the central nervous system. It also increases the memory, especially the memory that is short termed. The formation of RNA in the brain is increased, which significantly impacts the speed of the memory recall. These nootropic benefits vary in the population, so not all of the people could experience the same effects when administered with the same dosage of Pemoline.
Recommended dosage of Pemoline
This substance is extremely potent, so this factor should certainly be taken into consideration. Therefore, it is recommended to consult a medical professional before you decide to start a nootropic treatment using this chemical substance. The typical recommended dosage given in the studies and reviews is a single pill of about 37.5mg of Pemoline. The studies have shown that the best part of the day for you to take the pill and experience its top benefits is in the morning. Your medical professional should also be able to suggest a safe range for intake, which most would recommend at 50mg to 75mg. Everything which crosses the 110mg barrier is forbidden and not recommended under any circumstances.
Before you decide to start the treatment with this nootropic substance, along with the dosage and consultation with a medical professional, one must also consider all the side effects. The advice is to start with lower doses for a certain time and then gradually increasing it, while respecting the limit suggested by the sources.
Pemoline side effects
The side effects for this substance are numerous, but are minor. However, some of it are serious and should be taken into consideration when using this chemical substance. The most common side effects are insomnia and irritability. Users can also experience side effects such as nausea, headaches, hallucinations, increased heart rate, liver irritation, tics, and also the exacerbation of Tourette’s syndrome.
The toxicology studies have found out that this chemical affects liver negatively, so people who suffer from serious liver and kidney diseases, epilepsy, Tourette’s syndrome, and seizures should not use this compound. The combination with alcohol should be avoided, as well as the use in people who have a history of alcohol or drug abuse, both of which can affect the liver stance.