Tagcholine

Choline Capsules as the Ultimate Nootropic Supplement

For those who wish to try the latest wonders from the nootropic world, Choline capsules would be the right choice, which brings a solid foundation to neuroscience and medicine. In general, choline supplements are necessary for your brain to synthesize Acetylcholine, an important neurotransmitter to various brain functions, including conscious thought and memory. Choline supplements could be found in regular diet, especially with eggs and meat, yet some people, due to certain medical conditions and drug intake, need an additional quantity of Choline through supplements in order to make their brain, function properly. In this case, Choline pills can bring the additional Choline quantities and enhance the cognitive activity of the brain, ensuring a better maintenance and health of the neurons. When it comes to Choline supplements, there are numerous members of this supplement family, with all the formulations produced equally. Prices may vary with each Choline supplement, but those that are considered the cheapest have usually a less significant impact on the brain functions, probably due to poor absorption. So, what kind of Choline pills should you purchase? Discover more in this article, and start the safest way to a nootropic therapy.

Choline pills

Choline supplements – a general overview

The safetiness of this supplement is well determined by the fact that Choline supplements belong to the B4 group of vitamins, as fully recognized by the FDA in the U.S.A. This essential nutrient appears in abundant forms from Sphingomyelin and Phosphatidylcholine. As a significant precursor for the neurotransmitter Acetylcholine, Choline is also involved with brain functions such as memory, focus, attention control, muscle control, and learning. The beneficial effects of Choline can be seen in the prevention of Steatosis, or the fatty liver disease. That is when Choline removes fats from the liver and prevents the toxic effects of fat from affecting your liver.

The recommended daily dosage for Choline is somewhere between 425 and 550 mg in the diet. However, less than 10% of the population in the world can actually follow this. The supplement is water-soluble like any other presented member of the vitamin B group, so it is important to take it on a daily basis, replenishing the body in order to achieve the brain’s full potential. According to sources, it could be found in sunflower lecithin, soy lecithin, chicken, fish, eggs, and beef liver. Choline could also be found in various chemical forms, such as Choline citrate, Choline bitartarate, Phosphatidylcholine, Choline chloride, Lecithin in combination with Choline, and nowadays, the more popular Alpha GPC and Citicoline choline.

Different Choline supplements have different potencies, levels of cerebroactivity, prices, conversion rates to Acetylcholine, and bioavailabilities. If you compare these supplements by its costs, Lecithin wins, yet less than 10% of Choline is delivered when this supplement is administered, which means that you need to take a much higher dose for best effect. For a higher potency degree and also a higher price, one can have Phosphatidylcholine, and other forms of Choline salts like Citrate, Tartarate and Chloride. On the other hand, the bioavailability of such a group is low and does not improve your brain functions significantly. Probably the best and the most popular Choline supplements are Citicoline and Alpha GPC. Both are more expensive, but are more efficient, showing an increase levels with the brain functions and bringing the ultimate nootropic effect on cognitive functioning. Both are quickly absorbed and converted in the brain, which means that much a lesser dose is needed in order to enjoy the full benefits of these Choline precursors.

Why are Choline pills the best choice for you?

As mentioned in the beginning, Choline can convert into Sphingomyelin and Phosphatidylcholine, alongside Acetylcholine, which are essential for the brain’s functions and maintenance. These substances, which are normally present in low concentrations in the brain cells, act as insulators for the neuron’s electrical circuitry, which leads to a much quicker and efficient neurological communication process. Many brain conditions can lead to the disintegration of this lipid tunica, which can also lead to a poor brain communication between neurons that leads further to cognitive denial. Therefore, the absence of electrical transmission between neurons is unimaginable, so it is important to maintain the levels of these substances.

Choline supplements are also Acetylcholine precursors, potentiating the formation and effect of this powerful neurotransmitter. Acetylcholine maintains mental concentration and thinking, including memory development and consciousness. It helps in the transmission of the nerve signals from the brain, spinal cord, to the muscles, heart, lungs, glands, and the whole gastrointestinal system. As we age, the formation of Acetylcholine becomes lesser, potentially leading to Alzheimer’s disease and other mental conditions linked to memory deficiency. By taking Choline supplements, we could prevent these conditions, ensuring the complete formation of Acetylcholine without the neuronal damage linked to aging.

Recommended dosages for Choline pills

The FDA recommends a certain range of dosage for Choline supplements, and that is between 425 and 550 mg per day. In order to prevent brain deficiency, one must meet the daily dietary needs of an average person. A higher dose can improve the desired cognitive function, where some experts recommend the dosage at 3,000 mg daily from supplements such as Choline chloride and Bitartrate. A higher dose is recommended for these forms because Choline salts are degraded in the gastrointestinal tract by bacteria.

For highly potent Choline supplements, like Alpha GPC and Citicoline, it is important to take a lower dose because these supplements have a good absorption rate. Concerning Alpha GPC, a daily dosage of 500 mg is enough to enjoy its beneficial effects. Please pay attention to your diet, because you may as well take additional Choline through food like meat, fish, and eggs, so calculating your daily intake of Choline through food along with the supplements is essential. Vegetarians who certainly avoid meat should take a higher dose of these supplements in order to replenish the poor choline intake from their diet.

Since these supplements are considered to be the members of the vitamin B group, Choline supplements in such forms are safe and are even naturally found in the body and in our common diet. The risk for any side effect is low when the administration is practiced through the recommended dosage. The supplements are safe and can be tolerated by everyone, especially by young healthy adults. In some rare cases, some side effects are possible and are mostly sweating, appetite loss, and an increase in body temperature. Please, consider a consultation with a medical professional in order to start a much safer nootropic treatment with Choline supplements such are given in this review. It is also extremely important to maintain a healthy way of living while offering your brain an opportunity for better cognitive functions and preventing cognitive denial brought by many medical conditions, such as the Alzheimer’s disease.

Acetylcholine deficiency – Fight it with Nootropics

Acetylcholine, chemically, is an organic molecule (molecule containing a carbon-carbon or carbon-hydrogen bond). Its function is to behave like a neurotransmitter among humans and other living organisms. Neurotransmitters are chemicals produced inside the body that aid in transmitting electric signals from a neuron or a nerve ending to another target cell across a junction, known as synapse. The structure of the acetylcholine molecule includes an ester linkage between choline and acetic acid and is chemically represented as CH3COO (CH2)2N (CH3)3.

We hear much about vitamins and minerals, but very little about these important phospholipids, including acetylcholine.

Acetylcholine molecules are packaged inside synaptic membrane enclosed vesicles at a nerve ending, from where the molecules are ejected into the synaptic cleft. Acetylcholine molecules then diffuse across the cleft and bind to receptors in the membrane of the target post synaptic cell or neuron. This way signals and triggers are transmitted to render different bodily functions.

Acetylcholine has a crucial role in the central and peripheral nervous systems. It is also the primary transmitter to connect muscles to motor nerves via the neuromuscular junction. Acetylcholine is responsible for cognitive functioning, like memory formation, and muscle movement, coordination and communication by triggering muscle contraction as ordered by the brain. Hyperactivity or hypo-activity of the neurotransmitter can lead to problems and deter proper functioning of the body. To regulate the levels of acetylcholine, our body produces an enzyme called acetlycholinesterase.

This enzyme breaks down acetylcholine to recycle it and stop the electric signals. To further make sure that the levels of acetylcholine do not deplete, inhibitors are present that inhibit the action of acetlycholinesterase temporarily. The entire system is complex and concentration levels of all chemicals need to balanced and regulated carefully. In case there is an irregularity, it can lead to low levels of acetylcholine in the brain. Also, with age, levels of acetylcholine tend to decrease.

Unfortunately, according to a published report titled the National Health and Nutrition Examination Survey (NHANES) covering the period of 2003 and 2004, only about 10% of the population has a diet with sufficient amount of choline.  In other words, at least 90% of the population has a diet deficient in choline.  This deficiency is highest among older children, men, women, and particularly pregnant women.  The same survey also found that health care professionals are unlikely to recommend choline to patients or to recognize a deficiency.  Indeed only 6% of OB/GYNs surveyed were likely to recommend increased choline intake to pregnant women or women intending to become pregnant.

Acetylcholine deficiency can have devastating effects on the body. Patients face trouble with forming and retrieving memories. They forget faces, names, and other crucial information. They have a poor span of focus and cannot concentrate even for short period of times.  Their thoughts tend to jumble up and patients remain confused most of the times. Patients show uncontrolled muscle movements and often tremors pass through their bodies. In severe cases, acetylcholine deficiency can lead to dementia, Alzheimer’s disease and myasthenia gravis, a muscular disease.  In addition, liver function shows decline in people with a deficiency in acetylcholine and insufficient choline intake in their diets.

CholineInfo.org

courtesy of cholineinfo.org

Thus, it is imperative that proper levels of acetylcholine are maintained. Dietary sources are one way to do that. Egg yolks are a major source of precursors needed for the formation of acetylcholine molecule.  A web site by the name of cholineinfo.org has very good information on the choline properties of foods, including the graphic shown.

While it is preferred to get adequate choline intake from dietary sources, this is not always possible. Nootropic supplements are another way to boost up acetylcholine. They rapidly increase the neurotransmitter’s levels and lead to improved memory and better concentration.

One of the most bio-available forms of nootropic choline is Alpha GPC. L-Alpha glycerylphosphorylcholine or choline alfoscerate, as it is also known is a naturally occuring nootropic that possesses stand alone nootropic benefits as well as being a powerful synergizing compound. It is also found endogenously in our body in small amounts and is manufactured as an extract, a highly purified form of soy lecithin. Lecithin is the brain building nutrient found in eggs, dairy, meat and wheat germ).  Alpha GPC is an intermediate form of acetylcholine, a vital neurotransmitter that is responsible for learning, memory and movement related tasks.

Choline bitartrate is pure choline in a salt form that can be absorbed in the intestines with limited problems. Alpha GPC is also a precursor to choline that goes through several changes in the intestines and while crossing the blood-brain-barrier.  It is not as good at converting to acetylcholine, which should be the goal for any nootropic supplement used as a cholinergic.

Citicoline is also a choline source that, unlike choline bitartate or other choline supplements lower on the food chain, has stand alone nootropic benefits.  In addition to providing the choline support your brain craves, it also has some dopaminergic activity to help with mood and memory. Citicoline is a precursor to both choline and dopamine so increased energy, productivity, motivation and focus may accompany increased levels of dopamine which is the pleasure, wakefulness and reward-feedback neurotransmitter. Dopamine spills out when you feel accomplished or do something you enjoy or love.

Reversible acetylcholinesterase inhibitors, obtained from plants, are extracted and purified as yet another method to obtain the nootropic supplements. Huperzine A is one of them. It is obtained from Chinese moss and is part of many nootropic stacks, including Alpha Brain. Another nootropic supplement extracted from different species of flowering plants is galantamine. It is a powerful nootropic used to treat Alzheimer’s disease but has to be used cautiously and in small amounts.

The usage and dosage of nootropic supplements to treat acetylcholine deficiency are only to be assigned by a medical professional. Great care has to taken when consuming the supplements. If they are taken without consulting a doctor, acetlycholinesterase can be inhibited for long periods of time, leading to a whole set of new problems. Some negative side effects have shown in numerous patients. They include nausea, restlessness, and vomiting and decreased heart rate in some. So it is advisable that people with heart conditions and epilepsy avoid using Huperzine A and galantamine.

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